The Congenital Catheterization Research Collaborative (CCRC) will be a leader in measuring outcomes and improving care in pediatric and adult congenital interventional cardiology.
The Congenital Catheterization Research Collaborative (CCRC) will improve outcomes for patients with congenital heart disease through the development and execution of comprehensive outcomes research and innovation in care delivery in pediatric and adult congenital interventional cardiology.
History of the CCRC
In 2013, Dr. Christopher Petit (Children’s Healthcare of Atlanta) initiated a multicenter retrospective research study together with Dr. Bryan Goldstein (Cincinnati Children’s Hospital Medical Center). That study, which focused on predictors of outcomes following transcatheter therapy for congenital aortic valve stenosis, culminated in an oral presentation at the American Heart Association annual Scientific Sessions in 2014 and, subsequently, the publication of several manuscripts.
In 2015, based upon the success of this multicenter model, Drs. Petit and Goldstein invited Drs. Andrew Glatz (Children’s Hospital of Philadelphia) and Athar Qureshi (Texas Children’s Hospital), like-minded colleagues at other large-volume congenital heart programs, to embark on a new multicenter research project. This four-center project focused on predictors of outcomes following initial therapy (transcatheter or surgical) for infants with pulmonary atresia and intact ventricular septum, a complex form of congenital heart disease.
From the outset, it was clear that Drs. Petit, Goldstein, Glatz and Qureshi – who each had an independent track record of excellence in clinical cardiology and academic productivity – would come together to generate a collaborative study that was far more meaningful than could have been imagined by any single investigator.
The advantages of this multicenter academic collaboration were apparent to all: increased cohort size, greater generalizability of the results due to the broad number of institutions included, and consistency among centers with regards to quality of imaging and general approach in the catheterization laboratory. At the same time, all four participating institutions shared a similar programmatic vision: offering extensive and outstanding sub-specialty cardiac care to children and adults with congenital heart disease.
Further, all four centers have catheterization laboratories known for innovation in care delivery, excellence in outcomes, and a track record in making important clinical and academic contributions to the field of interventional pediatric cardiology. From this four investigator and center collaboration, the CCRC was born.
Since its formal inception in 2015, the collaborative has taken on two large multicenter projects:
- Outcomes and Associations Following Decompression of the Right Ventricle in Infants with Pulmonary Atresia with Intact Ventricular Septum
- A Comparison Between Patent Ductus Arteriosus Stent and Modified Blalock-Taussig Shunt as Palliation for Infants with Ductal-Dependent Pulmonary Blood Flow
Major results of first study, led by Drs. Petit and Goldstein, were presented at the American College of Cardiology in 2016 and subsequently published in Circulation: Cardiovascular Interventions in 2017. Subsequent ancillary efforts have been presented at national meetings and will be in press in the near future. The second study, led by Drs. Glatz and Qureshi, includes nearly 400 patients and was recently presented as an oral abstract by Dr. Glatz at the American Heart Association (AHA) Scientific Sessions 2016 in New Orleans, LA. This abstract received the “Outstanding Research Award in Pediatric Cardiology” from the AHA Council on Cardiovascular Disease in the Young. Subsequently, Dr. Qureshi presented an ancillary study detailing a novel approach to classification of ductal morphology as an oral abstract at the Pediatric and Adult Interventional Cardiac Symposium (PICS-AICS) 2017 in Miami, FL. Following on Dr. Glatz’s earlier success, Dr. Qureshi’s abstract presentation received the “Best Oral Abstract Award” from PICS-AICS 2017. In 2017, for the first time, the CCRC invited additional non-executive committee members to participate. A number of additional ancillary projects and new research projects are in various stages of development and completion at this time. Our bibliography may be found online.